Multimodal Biophotonic Monitoring of Local Drug Delivery to the Kidney
NATALIA A. SHUSHUNOVA 1; ARKADY S. ABDURASHITOV 2; EKATERINA S. PRIKHOZHDENKO 3; OKSANA A. MAYOROVA 1; VALENTINA O. PLASTUN 1; OLGA I. GUSLIAKOVA 1; ; OLEG A. KULIKOV 4; VALERY V. TUCHIN 1, GLEB B. SUKHORUKOV2; AND OLGA A. SINDEEVA 2;
1Saratov State University, Saratov, Russia
2 Skolkovo Institute of Science and Technology, Moscow, Russia
3 Moscow Institute of Physics and Technology (National Research University, Moscow, Russia
4Ogarev Mordovia State University, Saransk, Russia
Abstract
Modern treatment of acute and chronic kidney diseases often requires the use of potent therapeutic agents whose systemic administration may cause pronounced toxicity to the liver, cardiovascular system, and reproductive organs, thereby limiting the use of therapeutically effective doses. Conventional administration routes, including oral and intravenous delivery, do not provide preferential drug accumulation in the kidney: the administered compound is distributed throughout the body and undergoes metabolism and elimination, resulting in only a fraction of the initial dose reaching the target organ. A promising alternative is local drug delivery directly into the renal artery, which enables a high local concentration of the therapeutic agent during the first pass through the kidney while reducing the overall systemic drug burden. However, the effectiveness of this approach largely depends on the ability to control the retention and accumulation of delivery vehicles within the renal tissue, including micro- and nanostructured drug delivery systems and cells.
Until recently, optimization of targeted delivery parameters for therapeutic agents and their carriers has largely relied on sequential preclinical studies requiring the use of substantial numbers of experimental animals. The integration of biophotonic techniques provides an opportunity to complement this approach with monitoring of the processes directly determining delivery efficiency: fluorescence tomography enables visualization and quantitative assessment of the accumulation of fluorescently labeled carriers in the kidney, optical coherence tomography provides information on structural changes in renal tissue, while laser speckle contrast imaging allows real-time assessment of renal blood flow dynamics. The combined use of these techniques makes it possible to correlate carrier accumulation in the target organ with changes in tissue structure and local hemodynamics, thereby facilitating a transition from predominantly empirical parameter selection toward quantitatively controlled optimization of delivery conditions aimed at achieving effective accumulation of the therapeutic agent in the kidney while reducing systemic drug exposure and providing a basis for the development of safer and more effective strategies for local treatment of kidney diseases.
Speaker
Shushunova Natalia
Saratov State University
Russia
Discussion
Ask question
