Laser speckle-contrast imaging with light guidance by spatial light modulator for flow analysis (pilot study)
Igor O. Kozlov1, Dmitry D. Stavtsev1, Andrei A. Galiastov1, Dmitry V. Telyshev1,2;
1Sechenov University, Moscow, Russia; 2National Research University of Electronic Technology, Moscow, Zelenograd, Russia.
Abstract
This study examines a modification of the laser speckle contrast imaging method by incorporating a phase-only spatial light modulator into the optical setup. This device enables the control of the intensity distribution over the region of interest according to a user-defined mask, the correction of the wavefront, and the adjustment of statistical characteristics. To carry out the experiments, a setup was designed to generate and record speckle patterns using a suitable light source, a camera, lenses, mirrors, and opto-mechanical components. A light-splitting cube was used to introduce a spatial light modulator into the setup. The scattering fluid flow characteristics were investigated using a phantom made of polydimethylsiloxane with added TiO₂ to simulate scattering properties. The flow was set and controlled by a system comprising a microfluidic pump and a flow sensor. Studies were also conducted involving healthy volunteers to investigate the capability of recording perfusion and the physiological rhythms associated with it by controlling the light flux using a spatial modulator. The results demonstrated that the use of a spatial modulator does not disrupt the speckle pattern and can be applied to control the light flux in non-invasive diagnostic applications, whilst also highlighting the potential for further use of this modification.
Speaker
Igor O. Kozlov
Sechenov University
Russian Federation
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