Development of laser-induced thin-film hybrid carbon nanocomposites for neurointerfaces and stimulation of neuroregeneration

Abstract

Neurointerfaces require electrode materials with high conductivity, biocompatibility, and mechanical compliance with soft tissues. Traditional rigid electrodes damage neural tissue, causing inflammation and scarring, which impede neuroregeneration. Carbon nanomaterials and chitosan represent a promising alternative.
The aim of this work is to develop composites based on chitosan succinate modified with single-walled carbon nanotubes and reduced graphene oxide for neurointerfaces and stimulation of neuroregeneration.
Composites with a single-walled carbon nanotube/reduced graphene oxide ratio at a total concentration of 0.1 wt.% were fabricated. Laser processing (1064 nm, 100 ns, 30 kHz) and crosslinking with glutaraldehyde (0.5%, 30 min) were applied. Electrical resistance, mechanical properties, cyclic loading stability, and biodegradation were investigated.
The developed composites combine low impedance, mechanical compatibility with tissues, and stability under load. The absence of metals eliminates electromagnetic artifacts and cytotoxicity. The material is promising for EEG-based neurointerfaces, soft stimulating electrodes, and conduits for guided neuroregeneration. The biodegradability of the chitosan matrix enables the creation of temporary implants that do not require surgical removal.
The work was carried out within the framework of the state assignment of the Russian Ministry of Education and Science (Project FSMR-2024-0003).

Speaker

Viktoria Suchkova
1 Institute of Biomedical Systems, National Research University of Electronic Technology, Shokin Square 1, Zelenograd, 124498 Moscow, Russia 2 Institute for Bionic Technologies and Engineering, I.M. Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya Street 2-4, 119435 Moscow, Russia
Russia

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