Electrically conductive hybrid carbon nanomaterials for biointerfaces
U.E. Kurilova1,2, D.T. Murashko2, V.V. Suchkova1,2, I.A. Suetina3, M.V. Mezentseva3, L.I. Russu3, A.Yu. Gerasimenko1,2; 1Sechenov First Moscow State Medical University, Moscow, Russia; 2National Research University of Electronic Technology MIET, Zelenograd, Moscow, Russia; 3National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N.F. Gamaleya, Moscow, Russia
Abstract
The paper describes the studies results of connective tissue cells behaviour during electrical stimulation on the surface of hybrid materials based on carbon nanotubes and graphene oxide formed on a silicon substrate for use as interfaces for bioelectronic devices. Hybrid materials were obtained by laser processing of a combination of nanomaterials homogeneously distributed in a liquid dispersion, applied to the substrate by layer-by-layer deposition. Under the action of laser radiation with a wavelength of 1064 nm, connections were formed between the components of the dispersion with the formation of a strong porous framework. Experiments were carried out on in vitro electrical stimulation using the developed setup based on a culture plate, a pulse generator and electrodes connected to the samples. The number of fibroblast cells on the samples after electrical stimulation exceeds the number of cells in the control sample, the morphology of the cells is not changed compared to the control, which indicates the absence of toxic effects from the manufactured samples. The obtained results indicate the potential for the use of the developed hybrid materials in bioelectronic devices that stimulate ionic processes in the vital activity of cells in biological tissues.
The work was supported by the Ministry of Education and Science of the Russian Federation (project FSMR-2024-0003).
Speaker
Uliana Kurilova
Sechenov First Moscow State Medical University, National Research University of Electronic Technology MIET
Russia
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