DETECTION OF HUMAN CLEAR CELL RENAL CELL CARCINOMA THROUGH SPECTRAL OPTICAL PROPERTIES
Maria R. Pinheiro1,2, Maria I. Carvalho1,2, Valery V. Tuchin3,4,5, Luís M. Oliveira1,6
1Institute for Systems and Computer Engineering, Technology and Science (INESC TEC), Porto, Portugal
2Faculty of Engineering – Porto University, Porto, Portugal
3Institute of Physics and Science Medical Center, Saratov State University, Saratov, Russian Federation
4Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, Russian Federation
5Institute of Precision Mechanics and Control, Federal Research Center “Saratov Scientific Center of the Russian Academy of Sciences”, Saratov, Russian Federation
6Polytechnic Institute of Porto – School of Engineering, Porto, Portugal
Link to file with lecture: https://disk.yandex.ru/i/t_OGA7cutbC-JQ
Abstract
The internal composition, physiology, and morphology of biological tissues affect how light penetrates, is absorbed, and is scattered within the tissue. This light-tissue interaction can be characterized by a set of spectral optical properties, which are wavelength-dependent, and support the advancement of optical-based medical applications. The key optical properties include the absorption coefficient, the scattering coefficient, and the scattering anisotropy factor, which are considered the most essential. In addition, other parameters such as the reduced scattering coefficient and the light penetration depth are often evaluated. With the aim of evaluating the presence of clear cell renal cell carcinoma (CCRCC) in kidney tissues, this research focused on the estimation of the broadband spectral optical properties of healthy kidney tissue samples and CCRCC samples, between 200 and 1000 nm. Such an estimation resulted in the identification of cancer discriminating parameters, which allows for a comparative analysis to support clinical applications, for diagnostic, therapeutic and imaging purposes.
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Maria R. Pinheiro
Institute for Systems and Computer Engineering, Technology and Science (INESC TEC); Faculty of Engineering – Porto University
Portugal
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