ULTRAVIOLET TRANSPARENCY WINDOW CREATED BY BONDING TARTRAZINE MOLECULES TO TISSUE PROTEINS
Ana R. Guerra1,2, Luís R. Oliveira1,2, Gonçalo, O. Rodrigues2,3, Maria R. Pinheiro2,4, Maria I. Carvalho2,4, Valery V. Tuchin5,6,7, Luís M. Oliveira2,3
1Polytechnic Institute of Porto – School of Health, Porto, Portugal
2Institute for Systems and Computer Engineering, Technology and Science (INESC TEC), Porto, Portugal
3Polytechnic Institute of Porto – School of Engineering, Porto, Portugal
4Faculty of Engineering – Porto University, Porto, Portugal
5Institute of Physics and Science Medical Center, Saratov state University, Saratov, Russian Federation
6Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, Russian Federation
7Institute of Precision Mechanics and Control, Federal Research Center “Saratov Scientific Center of the Russian Academy of Sciences”, Saratov, Russian Federation
Link to file with lecture: https://disk.yandex.ru/d/4aX1Ntbaof-bkw
Abstract
The use of tartrazine (TZ), a food dye, in the creation of tissue transparency has recently created great interest in the research community. Studies published in 2024 showed that the transparency created in tissues for wavelengths longer than 600 nm is significantly greater than the transparency created by other optical clearing agents, allowing bigger light-probing depths and higher resolution in optical images. The reason for such bigger transparency is due to the absorption band of TZ located at 426 nm, where due to the Lorentz-oscillator model for dielectric particles, the fast absorption decay between 426 and 600 nm, allows TZ to provide a highly efficient refractive index (RI) matching mechanism in tissues for longer wavelengths. In this work, we show that the same efficient RI matching mechanism can also be observed in the ultraviolet range. Not only due to the application of the Lorentz-oscillator model to the absorption bands of TZ located in the ultraviolet, but also due to the interaction and binding of TZ molecules to proteins in muscle tissue, it was possible to identify a huge transparency window with two peaks located at 254 and 262 nm. Such results may be useful to develop new diagnostic or treatment protocols with ultraviolet light that can be applied to tissues with high protein contents.
Speaker
Luís M. Oliveira
Institute for Systems and Computer Engineering, Technology and Science (INESC TEC); Polytechnic Institute of Porto – School of Engineering, Porto, Portugal
Portugal
Report
File with report
Discussion
Ask question
