Study of statistics of laser speckle fields during immersive clearing of human skin with glucose solutions in polarized light
Anton A. Kharchenko1, Polina A. Timoshina1,2, Valery V. Tuchin1,2,3
1Saratov State University, Saratov, Russia
2Tomsk State University, Tomsk, Russia
3Institute of Precision Mechanics and Control, FRC "Saratov Scientific Center of the Russian Academy of Sciences", Saratov, Russia
Abstract
One of the modern research areas is the study of the effect of glucose on biological tissues. External glucose intake can affect the skin structure.
The aim of our research is to create a new method for analyzing speckle patterns for reflected scattered beams from human skin using optical clearing agents. By studying the statistics from the first to N-th order of speckle images, we obtain the dependences of the clearing time on the concentration of solutions. The degree of clearing is shown by the probability distribution function. The change in the structure of biological tissues is well described by the obtained autocorrelation function (ACF). Linear decay allows us to estimate short-range correlations that correspond to changes in the speckle size. Fluctuations show long-range correlations.
The nonlinearity of the clearing process due to dehydration and erythema, which changed the polarization and depolarization of the reflected radiation, was also studied. It was found that erythema polarizes light to some extent due to the influx of liquid.
Speaker
Anton A. Kharchenko
Saratov State University
Russia
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